Hydrochloric Acid → 6-(3-Phenylureido)nicotinic Acid

HRID 1878370ノート

反応式

HRID 1878370 の反応式
[C:1]1([NH:7][C:8](=[O:20])[NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Li+].O.Cl>CO>[C:1]1([NH:7][C:8](=[O:20])[NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 57917619HCID 57917619、化合物

生成物 1

HCID 579176586-(3-Phenylureido)nicotinic Acid収率 62.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

Methyl 6-(3-phenylureido)nicotinate (200 mg, 0.43 mmol) was dissolved in methanol (2 mL) at room temperature. Lithium hydroxide (100 mg, 4.17 mmol) was added, followed by water (10.5 mL). The mixture was heated to 50° C. and stirred overnight. The mixture was brought to pH 4-5 by addition of concentrated hydrochloric acid. The solid that had formed was then filtered and dried under vacuum to give the title compound (69 mg). MS (ESI) m/z 258.1[M+H]+

後処理

  1. customThe solid that had formed
  2. filtrationwas then filtered
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-fa63a2b679e444d189986a95767fecc5
出典データセット
uspto-grants-2012_11
特許番号
US08314091B2

反応ノート

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