Hydrazine hydrate (1:1) → HCID 66878617、化合物

HRID 1878371ノート

反応式

HRID 1878371 の反応式
[N:1]1[CH:6]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:4]=[CH:3][C:2]=1[C:12]([O:14]CC)=O.O.[NH2:18][NH2:19]>C(O)C>[NH:18]([C:12]([C:2]1[N:1]=[CH:6][C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][CH:3]=1)=[O:14])[NH2:19]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 13692208Diethyl pyrazine-2,5-dicarboxylate

生成物 1

HCID 66878617HCID 66878617、化合物収率 71.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
75 °C

実験手順

A mixture of diethyl pyrazine-2,5-dicarboxylate (1.75 g, 7.81 mmol) and ethanol (15 mL) was heated to 75° C. to obtain a homogeneous solution. After cooling to room temperature, a solution of hydrazine monohydrate (0.281 g, 7.03 mmol) in ethanol (3.5 mL) was added to the solution dropwise over 4 hours. After stirring at room temperature overnight, a solid had precipitated out of the reaction mixture. The solid was collected by filtration and dried under vacuum to give the title compound (1.05 g).

後処理

  1. customto obtain a homogeneous solution
  2. temperatureAfter cooling to room temperature
  3. customa solid had precipitated out of the reaction mixture
  4. filtrationThe solid was collected by filtration
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-941fc9a125a447aebfc20a695f23ac30
出典データセット
uspto-grants-2012_11
特許番号
US08314091B2

反応ノート

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