Thiazolidine → HCID 86659720、化合物

HRID 1878553ノート

反応式

HRID 1878553 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[S:18]1[CH2:22][CH2:21][NH:20][CH2:19]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:20]2[CH2:21][CH2:22][S:18][CH2:19]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

参加物

4

反応物 2

HCID 10444ThiazolidineHCID 49761343HCID 49761343、化合物

生成物 1

HCID 86659720HCID 86659720、化合物収率 78%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (51.4 mg, 0.195 mM), then thiazolidine (30.7 μL, 0.390 mM) was added to the solution and then the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture, the resulting residue was diluted with water and then extracted with ethyl acetate. The resulting extracts were combined, dried over anhydrous sodium sulfate, the solvent was distilled off and the resulting solid was washed with methanol to thus give the title compound (48.5 mg, yield: 78%).

後処理

  1. distillationThe solvent was distilled off from this reaction mixture
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off
  6. washthe resulting solid was washed with methanol

出典と根拠

ORDレコード
ord-6c73467d72b04dd38669dfa6275fc889
出典データセット
uspto-grants-2012_11
特許番号
US08314098B2

反応ノート

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