Sodium Hydroxide → 6-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

HRID 1878612ノート

反応式

HRID 1878612 の反応式
[Br:1][C:2]1[N:7]=[C:6]2[N:8](C(C3C=CC=CC=3)=O)[CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 73014178(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

生成物 1

HCID 247295876-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone (1 eq, 69.7 mmol, 23.4 g) is dissolved in MeOH (300 ml), then aqueous NaOH solution (1 M, 120 ml) is added and the resulting mixture is stirred for 18 h at r.t. The mixture is extracted with DCM and EtOAc, the extracts are combined and the solvents are removed in vacuo. Recrystallization from MeOH yields the title compound; [M+H]+=231.

後処理

  1. extractionThe mixture is extracted with DCM and EtOAc
  2. customthe solvents are removed in vacuo
  3. customRecrystallization from MeOH

出典と根拠

ORDレコード
ord-34d7a9f803954f57bee3507ac7c79743
出典データセット
uspto-grants-2012_11
特許番号
US08314112B2

反応ノート

読み込み中…