Acetonitrile → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine

反応式

[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[C:18](=[O:21])([O-])[O-].[K+].[K+].[C:24](#N)[CH3:25]>>[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH2:24][CH2:25][O:21][CH3:18])[CH2:14][CH2:13]1

参加物

反応物 3

HCID 6342Acetonitrile

HCID 11430Potassium Carbonate

HCID 574480384-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine

生成物 1

HCID 115297644-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(2-methoxyethyl)-piperidine

実験手順

Preparation according to Example 1: 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-piperidine (0.53 g, 1.64 mmol), acetonitrile (20 ml), potassium carbonate (0.45 g, 3.2 mmol) 1-bromo-2-methoxyethane (0.167 ml, 1.72 mmol). MS m/z (relative intensity, 70 eV) 315 (M+, 1), 271 (14), 270 (bp), 147 (10) 133 (9).