Triethylamine → HCID 59760051、化合物

HRID 1879128ノート

反応式

HRID 1879128 の反応式
C(N(CC)CC)C.[Cl:8][C:9]1[CH:10]=[C:11]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH3:26])=[C:21]([CH:25]=2)[C:22](Cl)=[O:23])[CH:12]=[CH:13][CH:14]=1.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:30][C:29]=1[CH3:40]>ClCCl.C(#N)C>[Cl:8][C:9]1[CH:10]=[C:11]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH3:26])=[C:21]([C:22]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:30][C:29]=3[CH3:40])=[O:23])[CH:25]=2)[CH:12]=[CH:13][CH:14]=1

参加物

6

反応物 3

HCID 8471TriethylamineHCID 23511836HCID 23511836、化合物HCID 59760053HCID 59760053、化合物

生成物 1

HCID 59760051HCID 59760051、化合物

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 6344Dichloromethane溶媒

実験手順

Triethylamine (74 ul, 0.53 mmol, 1.5 eq) was added to a suspension of 5-{[(3-chlorophenyl)methyl]oxy}-2-methylbenzoylchloride (105 mgs, 0.36 mmol) and ethyl (4-amino-3-methylphenyl)acetate (103 mg, 0.53 mmol, 1.5 eq) in dichloromethane (5 ml). The mixture was stirred at room temperature overnight. The mixture was then diluted with acetonitrile and purified by SCX cartridge (5 g) eluting with acetonitrile. Fractions containing product were combined and evaporated to give the title compound as a yellow gum, 174 mg. MS (ES+) m/z 452 [M+H]+ (C26H2635ClNO4).

後処理

  1. custompurified by SCX cartridge (5 g)
  2. washeluting with acetonitrile
  3. additionFractions containing product
  4. customevaporated

出典と根拠

ORDレコード
ord-913468b7e6774d879fec58c4a3078719
出典データセット
uspto-grants-2012_11
特許番号
US08314147B2

反応ノート

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