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Lithium Hydroxide → (9R,11S,14S)-14-tert-butyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.1 9,12]octacosa-1(26),2(28),3,5,22,24-hexaene-11-carboxylic acid

HRID 1879261
ノート
印刷プレビュー

反応式

HRID 1879261 の反応式
[Li+].[OH-].[C:3]([C@@H:7]1[NH:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][C:24]2[CH:32]=[C:20]([CH:21]=[CH:22][CH:23]=2)[C:19]2=[CH:33][C:15](=[CH:16][CH:17]=[CH:18]2)[CH2:14][O:13][C@H:12]2[CH2:34][N:9]([C@H:10]([C:35]([O:37]C)=[O:36])[CH2:11]2)[C:8]1=[O:39])([CH3:6])([CH3:5])[CH3:4]>C1COCC1.CCO.O>[C:3]([C@@H:7]1[NH:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][C:24]2[CH:32]=[C:20]([CH:21]=[CH:22][CH:23]=2)[C:19]2=[CH:33][C:15](=[CH:16][CH:17]=[CH:18]2)[CH2:14][O:13][C@H:12]2[CH2:34][N:9]([C@H:10]([C:35]([OH:37])=[O:36])[CH2:11]2)[C:8]1=[O:39])([CH3:6])([CH3:4])[CH3:5]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 58005141methyl (9R,11S,14S)-14-tert-butyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.1 9,12]octacosa-1(26),2(28),3,5,22,24-hexaene-11-carboxylate

生成物 1

HCID 58005162(9R,11S,14S)-14-tert-butyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.1 9,12]octacosa-1(26),2(28),3,5,22,24-hexaene-11-carboxylic acid

試薬・触媒・溶媒 1

HCID 18504229Ethanol tetrahydrofuran water溶媒

反応条件

温度
40 °C

実験手順

LiOH (3.0 eq.) was added to a 0.05 M solution of methyl (9R,11S,14S)-14-tert-butyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.1 9,12]octacosa-1(26),2(28),3,5,22,24-hexaene-11-carboxylate 104 in a mixture of THF:EtOH:H2O (2:1:1). The reaction mixture was stirred at 40° C. for 2 h then the solvent was evaporated under reduced pressure. Aqueous HCl (1N) was added to reach pH=6 and the mixture was evaporated to dryness to yield a dark solid which was used without further purification. MS (ES+) m/z 493 (M+H)+.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionAqueous HCl (1N) was added
  3. customthe mixture was evaporated to dryness
  4. customto yield a dark solid which
  5. customwas used without further purification

出典と根拠

ORDレコード
ord-f51d243a58e34598bf40da7545b86316
出典データセット
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08314062B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート