Sodium Hydroxide → HCID 18441970、化合物

HRID 1879408ノート

反応式

HRID 1879408 の反応式
N1C(C([O-])=O)=C[N:4]=[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:2]=1.[OH-:15].[Na+]>C(O)C>[CH2:13]([O:12][C:10]([C:3]1[N:4]=[N:4][C:3]([C:10]([OH:11])=[O:15])=[CH:2][CH:2]=1)=[O:11])[CH3:14]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86656579HCID 86656579、化合物

生成物 1

HCID 18441970HCID 18441970、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.15 g of ethyl pyrazine-3,6-dicarboxylate was dissolved in 34.5 mL of ethanol, and 5.64 mL of a 1 M aqueous sodium hydroxide solution was added thereto, followed by stirring at room temperature for 3.5 hours. The precipitated salt was collected by filtration and dissolved in a small amount of water, and then this solution was acidified (pH=2) with a 1 M aqueous hydrochloric acid solution, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated to obtain 435 mg of 6-(ethoxycarbonyl)pyridazine-3-carboxylic acid.

後処理

  1. filtrationThe precipitated salt was collected by filtration
  2. dissolutiondissolved in a small amount of water
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-28f0a939f0bb4d59a4260a7dd536615f
出典データセット
uspto-grants-2012_11
特許番号
US08314240B2

反応ノート

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