tert-butyl 7-(benzyloxy)-9H-carbazol-2-ylcarbamate → tert-butyl 7-hydroxy-9H-carbazol-2-ylcarbamate

HRID 1879532ノート

反応式

HRID 1879532 の反応式
C([O:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1

参加物

4

反応物 1

HCID 66933893tert-butyl 7-(benzyloxy)-9H-carbazol-2-ylcarbamate

生成物 1

HCID 58160239tert-butyl 7-hydroxy-9H-carbazol-2-ylcarbamate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To tert-butyl 7-(benzyloxy)-9H-carbazol-2-ylcarbamate (220 mg, 0.56 mmol) in 50 mL MeOH was added Palladium on activated carbon (80 mg). The mixture was stirred at rt under H2 atmosphere for 3 h. Solid was filtered off and the filtrate was concentrated to afford tert-butyl 7-hydroxy-9H-carbazol-2-ylcarbamate as a brown solid (165 mg, 100%). This material was used directly for the next reaction without purification. MS (ESI) m/z 619 (2M+Na+).

後処理

  1. filtrationSolid was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-14c08d0d97d24ea7912f7f0c5bfa75ef
出典データセット
uspto-grants-2012_11
特許番号
US08318132B2

反応ノート

読み込み中…