Glutaric anhydride → 5-(4-Methoxyphenyl)-5-oxopentanoic acid

HRID 1881036ノート

反応式

HRID 1881036 の反応式
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[Cl-].[Al+3].[Cl-].[Cl-].[C:13]([O:16][CH2:17][CH3:18])(=O)C>C1(OC)C=CC=CC=1>[CH3:13][O:16][C:17]1[CH:18]=[CH:4][C:3]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])=[CH:2][CH:1]=1

参加物

5

反応物 3

HCID 7940Glutaric anhydrideHCID 8857Ethyl AcetateHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 2668175-(4-Methoxyphenyl)-5-oxopentanoic acid収率 59%

試薬・触媒・溶媒 1

HCID 7519Anisole溶媒

実験手順

Glutaric anhydride (10.0 g) was dissolved in anisole (100 mL), aluminum chloride (25.7 g) was added, then stirred for three hours on ice. Ethyl acetate (300 mL) was added to the reaction solution, and the organic layer was washed with water (100 mL) and a saturated sodium chloride solution (100 mL). After drying on anhydrous sodium sulfate, filtration and vacuum condensation, the residue was washed with n-hexane to give the above-identified compound (11.5 g, yield 59%) as a colorless solid.

後処理

  1. washthe organic layer was washed with water (100 mL)
  2. dry with materialAfter drying on anhydrous sodium sulfate, filtration and vacuum condensation
  3. washthe residue was washed with n-hexane

出典と根拠

ORDレコード
ord-97cb2635ef024ad69aafba46ea483cc4
出典データセット
uspto-grants-2012_11
特許番号
US08318781B2

反応ノート

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