Nitric Acid → 3-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

HRID 1881161ノート

反応式

HRID 1881161 の反応式
[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([OH:15])=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8].[N+:16]([O-])([OH:18])=[O:17]>C(OCC)(=O)C.ClCCl>[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([OH:15])=[C:10]([N+:16]([O-:18])=[O:17])[C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8]

参加物

5

反応物 2

HCID 944Nitric AcidHCID 13575863478400-03-2

生成物 1

HCID 159829713-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

3-Chloro-5,6-dihydroxy-benzo[b]thiophene-2-carboxylic acid was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. The solution was stirred 10 min at room temperature and then it was poured into ice-cold water and extracted with ethyl acetate. The organic extracts were combined, dried and evaporated to dryness. The residue was recrystallized from acetic acid.

後処理

  1. additionit was poured into ice-cold water
  2. extractionextracted with ethyl acetate
  3. customdried
  4. customevaporated to dryness
  5. customThe residue was recrystallized from acetic acid

出典と根拠

ORDレコード
ord-39ee5300668549faa3c61461776962b2
出典データセット
uspto-grants-2012_11
特許番号
US08318785B2

反応ノート

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