Nitric Acid → 2-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

HRID 1881176ノート

反応式

HRID 1881176 の反応式
[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1.[N+:13]([O-])([OH:15])=[O:14]>C(OCC)(=O)C.ClCCl>[CH3:1][C:2]1[S:3][C:4]2[C:10]([N+:13]([O-:15])=[O:14])=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1

参加物

5

反応物 2

HCID 944Nitric AcidHCID 7369402-methyl-1,3-benzothiazole-5,6-diol

生成物 1

HCID 159831022-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Methyl-benzothiazole-5,6-diol was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. into. The solution was stirred 10 min at room temperature and then it was poured into ice water and extracted into ethyl acetate and evaporated. The product was purified by column chromatography using toluene-ethyl acetate-acetic acid 8:1:1 as the eluent.

後処理

  1. extractionextracted into ethyl acetate
  2. customevaporated
  3. customThe product was purified by column chromatography

出典と根拠

ORDレコード
ord-93c972d9802948868638b6370fcf9ec8
出典データセット
uspto-grants-2012_11
特許番号
US08318785B2

反応ノート

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