Hydrogen Bromide → 5-Hydroxy-6-methoxy-4-nitro-isobenzofuran-1,3-dione
反応式
C[O:2][C:3]1[C:4]([N+:16]([O-:18])=[O:17])=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[O:7][C:6]2=[O:15].Br>[Br-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(O)(=O)C>[OH:2][C:3]1[C:4]([N+:16]([O-:18])=[O:17])=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[O:7][C:6]2=[O:15]参加物
5
実験手順
5,6-Dimethoxy-4-nitro-isobenzofuran-1,3-dione (346 mg), 48% hydrogen bromide (1.5 ml), Acetic acid (15 ml) and benzyl triethylammonium bromide (37 mg) were heated at 140° C. for 3 hours. The acetic acid and water was removed in vacuo. The remainder was filtered through silica gel using a mixture of toluene, ethyl acetate and methanol (8:1:1) as eluent. Appropriate fractions were collected and evaporated.
後処理
- customThe acetic acid and water was removed in vacuo
- filtrationThe remainder was filtered through silica gel using
- additiona mixture of toluene, ethyl acetate and methanol (8:1:1) as eluent
- customAppropriate fractions were collected
- customevaporated
出典と根拠
- ORDレコード
- ord-4a19ad6978ea4769a64bb0740041eb0d
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318785B2
反応ノート
読み込み中…