2-Hydroxy-5-nitroindane → 5-amino-2,3-dihydro-1H-inden-2-ol

HRID 1881354ノート

反応式

HRID 1881354 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([OH:13])[CH2:7]2)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([OH:13])[CH2:7]2

参加物

3

反応物 1

HCID 36859272-Hydroxy-5-nitroindane

生成物 1

HCID 215550315-amino-2,3-dihydro-1H-inden-2-ol

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

5-nitro-indan-2-ol (450 mg, 2.5 mmol) was hydrogenated using Pd/C (10%, dry, 100 mg) and H2 balloon at 1 atm at room temperature. Pd/C was filtered off through a pad of celite and the mother liquid was concentrated to give the crude product, 5-Amino-indan-2-ol.

後処理

  1. customat room temperature
  2. filtrationPd/C was filtered off through a pad of celite
  3. concentrationthe mother liquid was concentrated

出典と根拠

ORDレコード
ord-c1e9be6881714f089dafe369bae5c784
出典データセット
uspto-grants-2012_11
特許番号
US08318790B2

反応ノート

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