HCID 178442423、化合物 → HCID 178442424、化合物

HRID 1881493ノート

反応式

HRID 1881493 の反応式
[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][N:10]2C(OC(C)(C)C)=O)[NH:7][CH:8]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][NH:10]2)[NH:7][CH:8]=1

参加物

3

反応物 1

HCID 178442423HCID 178442423、化合物

生成物 1

HCID 178442424HCID 178442424、化合物

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

tert-Butyl 2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]-2-[4-(5-fluoropyridin-2-yl)benzyl]pyrrolidine-1-carboxylate (45 mg, 0.089 mmol) was dissolved in trifluoroacetic acid (1 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford the title compound. 1H NMR (500 MHz, CD3OD) δ 8.48 (d, J=2.5 Hz, 1H), 8.28 (br s, 1H), 7.83 (dd, J=8.7, 4.2 Hz, 1H), 7.79 (d, J=8.0 Hz, 2H), 7.64 (td, J=8.5, 3.0 Hz, 1H), 6.97 (d, J=8.0 Hz, 2H), 6.86 (s, 1H), 3.45-3.39 (m, 3H), 3.24-3.17 (m, 1H), 2.52-2.41 (m, 1H), 2.45 (s, 2H), 2.33-2.25 (m, 1H), 2.22-2.13 (m, 1H), 1.91-1.82 (m, 1H), 1.22 (q, J=15.0, 7.5 Hz, 2H), 0.84 (t, J=7.5 Hz, 3H), 0.81 (s, 6H). (M+H) found: 407.

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-54f91ad7beb24140bae8eec3356ea7f0
出典データセット
uspto-grants-2012_11
特許番号
US08318767B2

反応ノート

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