Hydrochloric Acid → 5-Bromo-6-(hydroxymethyl)nicotinaldehyde

HRID 1881731ノート

反応式

HRID 1881731 の反応式
C[O:2][CH:3](OC)[C:4]1[CH:5]=[C:6]([Br:12])[C:7]([CH2:10][OH:11])=[N:8][CH:9]=1.Cl.[OH-].[Na+]>C(Cl)Cl>[Br:12][C:6]1[CH:5]=[C:4]([CH:3]=[O:2])[CH:9]=[N:8][C:7]=1[CH2:10][OH:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67428521{5-[Bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol

生成物 1

HCID 866648855-Bromo-6-(hydroxymethyl)nicotinaldehyde収率 87%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of {5-[bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol (98 mg, 0.374 mmol) and 1N HCl (3.26 mL, 3.26 mmol) in DCM (5 mL) was stirred overnight. DCM and 1M NaOH solution were added. Extraction, drying (Na2SO4), and filtration afforded 5-bromo-6-(hydroxymethyl)-3-pyridinecarbaldehyde (70 mg, 87%) as a brown oil pure enough to be used in the next step.

後処理

  1. extractionExtraction
  2. customdrying
  3. filtration(Na2SO4), and filtration

出典と根拠

ORDレコード
ord-d4a25755496243068795a2cba435d0c2
出典データセット
uspto-grants-2012_11
特許番号
US08318940B2

反応ノート

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