Diethyl Ether → Ethyl 2-(3-fluorophenoxy)acetate
反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].CCOCC>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH3:21]参加物
6
反応条件
- 温度
- 70 °C
実験手順
To a solution of 3-fluorophenol (2.24 g, 20.0 mmol) in DMF (40 mL) is added potassium carbonate (3.03 g, 22.0 mmol) and ethyl bromoacetate (2.34 mL, 21.0 mmol), and the mixture is stirred at 70° C. for 18 h. The mixture is cooled to RT, Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled to give 3.2 g of the product 432.
後処理
- temperatureThe mixture is cooled to RT
- washthe mixture is washed with water, brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customThe filtrate is evaporated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-99356e1627bb4107842395945d2688b4
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741493B2
反応ノート
読み込み中…