Hydrochloric Acid → 1-[2-(1,3-Dioxolan-2-yl)-1,3-thiazol-5-yl]ethane-1,2-diol
反応式
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[S:7][C:8]([C:11](=[O:17])[C:12](OCC)=[O:13])=[CH:9][N:10]=1.[BH4-].[Na+].Cl>C(O)C>[O:3]1[CH2:4][CH2:5][O:1][CH:2]1[C:6]1[S:7][C:8]([CH:11]([OH:17])[CH2:12][OH:13])=[CH:9][N:10]=1参加物
5
実験手順
To a solution of ethyl [2-(1,3-dioxolan-2-yl)-1,3-thiazol-5-yl](oxo)acetate (2.00 g) in ethanol (20 mL) was slowly added sodium borohydride (0.50 g). The reaction mixture was stirred at room temperature for 1 hr, 6M hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated to give the title compound (1.50 g, yield 89%) as a colorless oil. MS: 218 (MH+).
後処理
- extractionthe mixture was extracted with ethyl acetate
- washThe ethyl acetate layer was washed with saturated brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-ee859a4ebfa44a26ae315381f221b6ff
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318746B2
反応ノート
読み込み中…