Hydrochloric Acid → Benzoic acid, 2-(carboxymethoxy)-

HRID 1882322

反応式

HRID 1882322 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:18])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][C:14]([O:16]C)=[O:15].Cl>>[C:14]([CH2:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[C:5]([OH:18])=[O:4])([OH:16])=[O:15]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11287524Methyl 2-(2-methoxy-2-oxoethoxy)benzoate

生成物 1

HCID 69461Benzoic acid, 2-(carboxymethoxy)-収率 78.2%

反応条件

温度
80 °C

実験手順

To 10% Solution of Sodium hydroxide (475 mL) was added 2-Methoxycarbonylmethoxy-benzoic acid methyl ester 5 (95 grams, 424 mmol) and heated to 80° C. for 4 hours. Reaction mixture was cooled to room temperature and pH adjusted so 2 with dilute Hydrochloric acid. The crude 80 was purified by dissolving in 10% NaOH and precipitating by acidifying with HCl, to get pure 80 (65 grams, 78.2%) as white powder. M.p: 189-192° C.

後処理

  1. customReaction mixture
  2. temperaturewas cooled to room temperature
  3. customThe crude 80 was purified
  4. dissolutionby dissolving in 10% NaOH
  5. customprecipitating

出典と根拠

ORDレコード
ord-a54d75e8868f418c84fe5470f362eb4c
出典データセット
uspto-grants-2012_11
特許番号
US08318973B2

関連ノート

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