N-Benzyl 2-(Carbobenzyloxyamino)-3-Methoxypropionamide → 2-amino-N-benzyl-3-methoxypropanamide
反応式
[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH:14]C(OCC1C=CC=CC=1)=O)[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH2:1]([NH:8][C:9](=[O:25])[CH:10]([NH2:14])[CH2:11][O:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of 12 (122.8 mg, 0.36 mmol) in methanol (2.0 mL) was added 10% Pd—C (11 mg) and the mixture stirred at room temperature in the presence of H2 gas for 75 min. Celite was added to the reaction mixture and the catalyst was removed by filtration. The clear filtrate was evaporated in vacuo to give pure 13 as a clear viscous oil (72 mg, 97%): Rf 0.30 (5% MeOH/CHCl3).
後処理
- additionCelite was added to the reaction mixture
- customthe catalyst was removed by filtration
- customThe clear filtrate was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-7bf14b3a8725413cb290f5016c293b3a
- 出典データセット
- uspto-grants-2004_07
- 特許番号
- USRE038551E1
反応ノート
読み込み中…