Hexylamine → [2-(Hexylamino)phenyl]methanol

HRID 1883450

反応式

HRID 1883450 の反応式
Br[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH2:10]([NH2:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[CH2:10]([NH:16][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

3

反応物 2

HCID 8102HexylamineHCID 728502-Bromobenzyl alcohol

生成物 1

HCID 15084054[2-(Hexylamino)phenyl]methanol収率 81%

実験手順

Using the general procedure, 2-bromobenzyl alcohol (187 mg, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol) at 90° C. for 22 h. Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (6:1) as eluent afforded the desired product as a colorless liquid (168 mg, 81% yield). Rf=0.7 (hexane/ethyl acetate=2:1).

後処理

  1. customPurification of the crude product by column chromatography on silica gel

出典と根拠

ORDレコード
ord-687dd388084749118e1149474476f5de
出典データセット
uspto-grants-2004_07
特許番号
US06759554B2

関連ノート

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