Ethanolamine → HCID 505745、化合物
反応式
CO.C(O[C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7])C.[CH2:26]([CH2:28][NH2:29])[OH:27]>O>[OH:27][CH2:26][CH2:28][NH:29][C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7]参加物
5
実験手順
To the solution of methanol (20 ml) was added 4-(1H-5-indazolylamino)-2-methylthio-5-pyrimidinecarboxylic acid ethyl ester (1 g) prepared from preparation example 1, added ethanol amine (7 ml) at room temperature, and refluxed for 4 hr. The reaction mixture was cooled and slowly added H2O (40 ml) at 20° C. and stirred for 0.5 hr. The reaction mixture was filtered, washed with 25% aqueous methanol solution (10 ml), obtained the desired compound (0.75 g, 72%)