Trifluoroacetic acid → HCID 69758844、化合物

HRID 1883648ノート

反応式

HRID 1883648 の反応式
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([O:8]C(C)(C)C)=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19].[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69911586HCID 69911586、化合物

生成物 1

HCID 69758844HCID 69758844、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of t-butyl 4-amino-3-[(N-methylacetylamino)methyl]benzoate (2.13 g, 7.65 mmole) in CH2Cl2 (150 mL) at RT was added TFA (30 mL). After 12 hr, the reaction solution was concentrated to an oil and dried under high vacuum overnight. The resulting residue was washed with hexanes and Et2O to afford the title compound (2.56 g, 7.60 mmole) as an off-white solid. This compound was used without further purification: MS (ES) m/e 223 (M+H-TFA)+.

後処理

  1. concentrationthe reaction solution was concentrated to an oil
  2. customdried under high vacuum overnight
  3. washThe resulting residue was washed with hexanes and Et2O

出典と根拠

ORDレコード
ord-6aa400d9f65c45779b865b33c03a3670
出典データセット
uspto-grants-2004_07
特許番号
US06762201B1

反応ノート

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