ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Diisopropylethylamine → HCID 23508314、化合物

HRID 1883709
ノート
印刷プレビュー

反応式

HRID 1883709 の反応式
[C:1]1([CH3:21])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[O:9][C:10]2[CH:16]=[C:15]([CH2:17][C:18]([OH:20])=O)[CH:14]=[CH:13][C:11]=2[N:12]=1.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1.C(N(C(C)C)CC)(C)C.Cl.[NH2:56][C:57]1[CH:58]=[CH:59][C:60]([CH:66]([CH3:73])[CH2:67][C:68]([O:70][CH2:71][CH3:72])=[O:69])=[C:61]2[C:65]=1[CH2:64][CH2:63][CH2:62]2>CN(C)C=O>[C:1]1([CH3:21])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[O:9][C:10]2[CH:16]=[C:15]([CH2:17][C:18]([NH:56][C:57]3[CH:58]=[CH:59][C:60]([CH:66]([CH3:73])[CH2:67][C:68]([O:70][CH2:71][CH3:72])=[O:69])=[C:61]4[C:65]=3[CH2:64][CH2:63][CH2:62]4)=[O:20])[CH:14]=[CH:13][C:11]=2[N:12]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 235083152-(2-(O-tolylamino)benzo[d]oxazol-6-yl)acetic acidHCID 23508318HCID 23508318、化合物

生成物 1

HCID 23508314HCID 23508314、化合物収率 104.6%

試薬・触媒・溶媒

1
HCID 6228Dimethylformamide溶媒2 回

実験手順

A mixture of 2-(2-o-tolylamino-benzoxazol-6-yl)acetic acid (0.398 g, Reference Example 2), O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (0.59 g) and diisopropylethylamine (0.24 g) in dimethylformamide was stirred at room temperature for 10 minutes and then treated with a solution of ethyl 3-[7-amino-indan-4-yl]-butanoate hydrochloride (0.4 g, Reference Example 5) in dimethylformamide. After shaking and then allowing to stand at room temperature for 16 hours the reaction mixture was evaporated under high vacuum. The residual red oil was dissolved in ethyl acetate and the solution was washed with 5% aqueous sodium bicarbonate, then with water, then dried over sodium sulfate and then evaporated to give the title compound (0.754 g) as an oil.

後処理

  1. stirringAfter shaking
  2. waitto stand at room temperature for 16 hours
  3. customthe reaction mixture was evaporated under high vacuum
  4. dissolutionThe residual red oil was dissolved in ethyl acetate
  5. washthe solution was washed with 5% aqueous sodium bicarbonate
  6. dry with materialwith water, then dried over sodium sulfate
  7. customevaporated

出典と根拠

ORDレコード
ord-37c3801a16e24ff08da15562fe7869e1
出典データセット
uspto-grants-2004_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06762199B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート