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3-Methoxy-2-methyl-3-oxopropanoic acid → N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxy-2-methyl-3-oxopropanoic acid | HCID 300693 | — |
| 反応物 | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | N-[4-(3-Fluoro-benzyloxy)-phenyl]-2-methyl-malonamic Acid Methyl Ester | HCID 69008808 | — |
反応手順
The title compound is prepared in analogy to example 2, starting from 4-(3-fluoro-benzyloxy)-phenylamine (as prepared in example 1b) and 2-methyl-malonic acid monomethyl ester (Nader et al., Chem. Ber. 1986, 119, 1196). Yield after flash-chromatography with dichloromethane/methanol 98:2: 40%. Colorless solid. Mp=119° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06762320B2 |
| 出典データセット | uspto-grants-2004_07 |
| ORD ID | ord-e28e7cb9af8f4edb87257a17855c074a |
| 出典メモ | uspto-grants-2004_07 |