HCID 12150103、化合物 → HCID 12150104、化合物

HRID 1884608ノート

反応式

HRID 1884608 の反応式
C([O:5][C:6]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]=2[O:37][CH3:38])=[O:20])=[CH:10][CH:9]=1)=[O:7])(C)(C)C>[Au].C(O)(C(F)(F)F)=O>[C:28]([C:26]1[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]([O:37][CH3:38])=[C:22]([NH:21][C:19](=[O:20])[NH:18][C:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]([C:6]([OH:7])=[O:5])=[CH:9][CH:10]=2)[CH:27]=1)([CH3:31])([CH3:29])[CH3:30]

参加物

4

反応物 1

HCID 12150103HCID 12150103、化合物

生成物 1

HCID 12150104HCID 12150104、化合物収率 89%

試薬・触媒・溶媒 2

HCID 23985Gold触媒HCID 6422Trifluoroacetic acid溶媒

実験手順

To a 0° C. solution of 10 mL of TFA was added 878 mg (1.9 mmol) of 4-[3-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalene-1-carboxylic acid tert-butyl ester. The clear, light gold reaction was allowed to warm to room temperature, and kept there for 1 h. After this time, the reaction was concentrated in vacuo, and then diluted with toluene. The toluene was then removed in vacuo and the pale white solid was triturated with ether to provide 682 mg (89%) of the title compound.

後処理

  1. concentrationAfter this time, the reaction was concentrated in vacuo
  2. additiondiluted with toluene
  3. customThe toluene was then removed in vacuo
  4. customthe pale white solid was triturated with ether

出典と根拠

ORDレコード
ord-a74cbf86aec6495b880a69bcde8de4c6
出典データセット
uspto-grants-2004_07
特許番号
US06765009B2

反応ノート

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