Ammonia → 2,6-Dichlorobenzenesulfonamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH3:13].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9]([NH2:13])(=[O:11])=[O:10]参加物
5
実験手順
A solution of 2,6-dichlorobenzenesulfonyl chloride (10.50 g, 42.77 mmol) in 100 mL of pyridine was added into 100 mL of pyridine dropwise while anhydrous ammonia gas was passing through the solution simultaneously for 4 hours at 0° C. The mixture was acidified to pH>1 with 6N aq. HCl, then extracted with ethyl acetate. The combined organic layer was then dried (Na2SO4) and concentrated to give the desired product (8.69 g, 90%). EI-MS (m/z) 225.0, 227.1 (M−).
後処理
- extractionextracted with ethyl acetate
- dry with materialThe combined organic layer was then dried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4e2e6a4389f5451d897a37467976ebb2
- 出典データセット
- uspto-grants-2004_07
- 特許番号
- US06767922B2
反応ノート
読み込み中…