Diphenyl Ether → 3-butyryl-8-acetyl-4(1H)-quinolone

HRID 1885172

反応式

HRID 1885172 の反応式
[C:1]([C:6](=[CH:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20](=[O:22])[CH3:21])[C:7]([O:9]CC)=O)(=[O:5])[CH2:2][CH2:3][CH3:4].C1(OC2C=CC=CC=2)C=CC=CC=1>CCOCC>[C:1]([C:6]1[C:7](=[O:9])[C:19]2[C:14](=[C:15]([C:20](=[O:22])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 7583Diphenyl EtherHCID 178450482HCID 178450482、化合物

生成物 1

HCID 103777553-butyryl-8-acetyl-4(1H)-quinolone収率 70.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Ethyl 2-butyryl-3-(2-acetylphenylamino)acrylate (14.8 g, 48.8 mmol) was added to boiling diphenyl ether (50 ml) and heated at reflux for 3.5 hours. After cooling, the solution was poured into ether, and the solid filtered off and washed with ether to obtain 3-butyryl-8-acetyl-4(1H)-quinolone (8.8 g), contaminated with some diphenyl ether. This material was used without further purification.

後処理

  1. temperatureheated
  2. temperatureat reflux for 3.5 hours
  3. temperatureAfter cooling
  4. filtrationthe solid filtered off
  5. washwashed with ether

出典と根拠

ORDレコード
ord-b0f96a80b7ba468191ba8632e0f3bb51
出典データセット
uspto-grants-1992_09
特許番号
US05143920

関連ノート

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