Methylamine hydrochloride → HCID 135624223、化合物
反応式
C(O[C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][N:5]=1)C.Cl.[CH3:15][NH2:16]>C(O)C>[ClH:13].[Cl:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][NH:5][C:4]2=[N:16][CH3:15])=[CH:8][CH:9]=1参加物
4
実験手順
A suspension of 110.5 g of 1-ethoxy-6-chloro-3H-isoindole and 41.9 g of methylamine hydrochloride in 1100 ml of ethanol was heated to boiling under reflux for 4 hours under argon, whereupon it was cooled to 2°, the separated crystals were filtered off under suction and recrystallized from ethanol. There are obtained 91.0 g of 6-chloro-1-(methylimino)isoindoline hydrochloride as white crystals with a m.p. of >250°.
後処理
- temperaturewas heated
- temperatureunder reflux for 4 hours under argon, whereupon it
- temperaturewas cooled to 2°
- filtrationthe separated crystals were filtered off under suction
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-bb7ca7d94d1945d08cfc4659bf3f229d
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05143912
反応ノート
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