Betamethasone → Cortisone

HRID 1885569

反応式

HRID 1885569 の反応式
C[C@@H:2]1[C@:19]([OH:28])([C:20]([CH2:22][O:23]P([O-])([O-])=O)=[O:21])[C@:18]2([CH3:29])[C@H:4]([C@H:5]3[C@:15](F)([C@@H:16]([OH:30])[CH2:17]2)[C@:14]2([CH3:32])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1.[Na+].[Na+].C[C@@H]1[C@](O)(C(CO)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1>>[CH3:32][C@@:14]12[C@H:15]3[C:16]([CH2:17][C@:18]4([CH3:29])[C@@:19]([OH:28])([C:20]([CH2:22][OH:23])=[O:21])[CH2:2][CH2:3][C@H:4]4[C@@H:5]3[CH2:6][CH2:7][C:8]1=[CH:9][C:10](=[O:11])[CH2:12][CH2:13]2)=[O:30]

参加物

3

反応物 2

HCID 9782BetamethasoneHCID 65478Betamethasone Sodium Phosphate

生成物 1

HCID 222786Cortisone

実験手順

Eight rabbits of the New Zealand breed were used, weighing approximately 2 kg. In the right eye of each animal, 0.8 ml/week of Bentelan Depot (equivalent to 4 mg betametasone) were instilled for 4 weeks. The left eye was kept as control. The medicament, administered subconjunctivally, brought about an increase of the intraocular tension in the first week, reached its peak in the second week and then remained constant until the fifth week.

後処理

  1. temperaturean increase of the intraocular tension in the first week
  2. customremained constant until the fifth week

出典と根拠

ORDレコード
ord-ed12391bc7ef41f78560f3533f2d9e73
出典データセット
uspto-grants-1992_09
特許番号
US05145871

関連ノート

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