p-Toluenesulfonic acid → HCID 15228403、化合物

HRID 1885602ノート

反応式

HRID 1885602 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][CH:11]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:20]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][CH:11]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 198793472-{[(3,4-Dichlorophenyl)sulfanyl]methyl}pentanedioic acid

生成物 1

HCID 15228403HCID 15228403、化合物収率 1,656.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

A mixture of 2-(3,4-dichlorophenylthiomethyl)glutaric acid (3.00 g), methanol (30 ml), and p-toluenesulfonic acid (0.09 g) was stirred at 40° C. for 2.5 hours. The reaction mixture was concentrated in vacuo, and the resulting residue was purified by flash column chromatography on silica by eluting with chloroform/ethanol (10:1) to give 2.92 g of 3-(3,4-dichlorophenylthio)-2-(2-methoxycarbonylethyl)propionic acid as an oil.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe resulting residue was purified by flash column chromatography on silica
  3. washby eluting with chloroform/ethanol (10:1)

出典と根拠

ORDレコード
ord-d33357b1d12e4b5994000da56ddcd000
出典データセット
uspto-grants-1992_09
特許番号
US05145869

反応ノート

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