反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[Br-].COC(C1C=CC=CC=1C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=O.O1C=CC=C1C[CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[CH2:54][C:55]([O:57][CH3:58])=[O:56].C(Cl)C1C=CC=CC=1.C1(CC([O-])=O)C=CC=CC=1.[C-]#N.[K+].C1(CC#N)C=CC=CC=1.S(=O)(=O)(O)O>CS(C)=O.CO>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=2[CH2:54][C:55]([O:57][CH3:58])=[O:56])=[CH:4][CH:3]=1参加物
11
反応物 8
生成物 1
試薬・触媒・溶媒 2
実験手順
Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate was prepared from 4-fluorobenzaldehyde and (o-methoxycarbonylbenzyl)triphenylphosphonium bromide by a route similar to that described in Example 3 for the preparation of methyl 2-[2-(2-furyl)ethyl]phenylacetate. In this instance, the benzyl chloride was converted into the phenylacetate by treatment with potassium cyanide in DMSO and, then, methanolysis of the resulting phenylacetonitrile with sulphuric acid in methanol.
出典と根拠
- ORDレコード
- ord-51a733eb0d084f3f86d134e975174bbe
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05145954
関連ノート
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