Methanol → 1-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one

HRID 1885899ノート

反応式

HRID 1885899 の反応式
C(=[N:8][N:9]1[CH:13]2[CH2:14][CH:15]([OH:17])[CH2:16][CH:12]2[N:11]([CH2:18][CH2:19][CH3:20])[C:10]1=[O:21])C1C=CC=CC=1.CO>[Pd].C(O)(=O)C>[NH2:8][N:9]1[CH:13]2[CH2:14][CH:15]([OH:17])[CH2:16][CH:12]2[N:11]([CH2:18][CH2:19][CH3:20])[C:10]1=[O:21]

参加物

5

反応物 2

HCID 887MethanolHCID 679048761-Benzylideneamino-3-propyl-5-hydroxyhexahydrocylopenta[d]imidazol-2(1H)-one

生成物 1

HCID 198784021-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one収率 103%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

反応条件

温度
15 °C

実験手順

The compound of step (f) (7.0 g) was added to a solution of methanol (280 ml) and acetic acid (2.25 ml) containing 10% Pd on carbon (2.5 g) and the resulting mixture stirred at 15° C. under an atmosphere of hydrogen for 3 days. The catalyst was removed by filtration through Celite and concentration of the filtrate in vacuo gave the desired product as an oil (5.0 g).

後処理

  1. customThe catalyst was removed by filtration through Celite and concentration of the filtrate in vacuo

出典と根拠

ORDレコード
ord-a2063fc0b2c143bfb121119341426eab
出典データセット
uspto-grants-1992_09
特許番号
US05147885

反応ノート

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