4-(2-Pyrimidinyl)-3-butynol → HCID 19876764、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][OH:11]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]参加物
4
実験手順
4-(2-Pyrimidinyl)-3-butynol (1.5 g) in ethanol (40 ml) was added to pre-reduced 10% palladium on charcoal (50% aqueous paste) in ethanol (60 ml) and hydrogenated at room temperature and atmospheric pressure. The catalyst was removed by filtration through hyflo and the solvent evaporated in vacuo. The residual oil was purified by FCC. Elution with System C (19:1) and (9:1) gave the title compound as a pale yellow oil (1.32 g)
後処理
- customThe catalyst was removed by filtration through hyflo
- customthe solvent evaporated in vacuo
- customThe residual oil was purified by FCC
- washElution with System C (19:1) and (9:1)
出典と根拠
- ORDレコード
- ord-1d5286cdfd2841c29128112fa4c63b42
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05149698
反応ノート
読み込み中…