6-(2-Pyrimidinyl)-5-hexynol → 6-(Pyrimidin-2-YL)hexan-1-OL

HRID 1886012ノート

反応式

HRID 1886012 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

参加物

4

反応物 1

HCID 198767486-(2-Pyrimidinyl)-5-hexynol

生成物 1

HCID 198767736-(Pyrimidin-2-YL)hexan-1-OL収率 29.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of 6-(2-pyrimidinyl)-5-hexynol (3.09 g) in ethanol (100 ml) was added to a pre-hydrogenated suspension of 10% palladium on charcoal (1.05 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure, filtered and evaporated in vacuo. The residual oil was purified by FCC eluting with ether and System C (99:1-85:15) to give the title compound as a pale yellow oil (0.93 g).

後処理

  1. filtrationpressure, filtered
  2. customevaporated in vacuo
  3. customThe residual oil was purified by FCC
  4. washeluting with ether and System C (99:1-85:15)

出典と根拠

ORDレコード
ord-4ab2a6f5eed9480ca3382287c4069849
出典データセット
uspto-grants-1992_09
特許番号
US05149698

反応ノート

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