1,6-Dibromohexane → HCID 19876744、化合物

HRID 1886017ノート

反応式

HRID 1886017 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br.[OH-].[Na+]>O.CCOCC>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1

参加物

6

反応物 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 198767736-(Pyrimidin-2-YL)hexan-1-OL

生成物 1

HCID 19876744HCID 19876744、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-pyrimidinehexanol (1.18 g), 1,6-dibromohexane (4 ml), 50% sodium hydroxide (4 ml) and TAB (100 mg) was vigorously stirred at room temperature for 17 h, then diluted with water (40 ml) and ether (50 ml). The organic phase was dried and evaporated in vacuo to an oil which was purified by FCC. Elution with hexane followed by hexane-ether (1:1) gave the title compound as a colourless oil (670 mg), t.l.c. (ether) Rf 0.24

後処理

  1. customThe organic phase was dried
  2. customevaporated in vacuo to an oil which
  3. customwas purified by FCC
  4. washElution with hexane

出典と根拠

ORDレコード
ord-379effd80aac498b9e80242992b36f7a
出典データセット
uspto-grants-1992_09
特許番号
US05149698

反応ノート

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