Sodium Hydroxide → HCID 19876826、化合物

HRID 1886039ノート

反応式

HRID 1886039 の反応式
CS([C:5]1[N:9]([CH3:10])[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=1)(=O)=O.[C:15]([NH:18][CH2:19][CH2:20][NH2:21])(=[O:17])[CH3:16].[OH-].[Na+]>O>[CH3:10][N:9]1[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[N:6]=[C:5]1[NH:21][CH2:20][CH2:19][NH:18][C:15](=[O:17])[CH3:16]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 66082N-(2-aminoethyl)acetamideHCID 6407151H-benzimidazole, 1-methyl-2-(methylsulfonyl)-

生成物 1

HCID 19876826HCID 19876826、化合物収率 30%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-methylsulfonyl-1-methyl-1H-benzimidazole (7.0 g, 0.033 mol) and N-acetylethylenediamine (17.0 g, 0.167 mol) was heated at 120°-125° C. for 8 hours. The mixture was cooled, diluted with H2O, made basic (pH8) with 2.5N NaOH, and filtered. The filtrate was extracted with EtOAc, and the combined extracts were washed with brine, dried, and concentrated to give a yellow solid 2.3 g (30%).

後処理

  1. temperaturewas heated at 120°-125° C. for 8 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. extractionThe filtrate was extracted with EtOAc
  5. washthe combined extracts were washed with brine
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-30c1f321743f4c65893aa24b4c8df49f
出典データセット
uspto-grants-1992_09
特許番号
US05149700

反応ノート

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