Sodium Carbonate → HCID 19876796、化合物
反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:12]([NH:15][CH2:16][CH2:17][NH2:18])(=[O:14])[CH3:13].C(=O)([O-])[O-].[Na+].[Na+]>CC(C)CCO>[N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[NH:18][CH2:17][CH2:16][NH:15][C:12](=[O:14])[CH3:13]参加物
5
実験手順
A mixture of 2-chloroquinoline (10.00 g, 0.061 mol), N-acetylethylenediamine (6.24 g, 0.061 mol), sodium carbonate (6.48 g, 0.061 mol), and 3-methyl-1-butanol (125 mL) was heated under reflux for 3 days. The mixture was cooled, filtered, and the filtrate was concentrated to give 16.3 g (>100%) of a yellow oil. Purification by flash chromatography (eluent 5% MeOH/CHCl3 ; 10% MeOH/1% Et3N/CHCl3) gave 6.8 g (49%) of a yellow oil.
後処理
- temperaturewas heated
- temperatureunder reflux for 3 days
- temperatureThe mixture was cooled
- filtrationfiltered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-1b70397d624c454bba83e39458a9e1f2
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05149700
反応ノート
読み込み中…