Ethanolamine → HC Yellow No. 2

HRID 1886049

反応式

HRID 1886049 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH2:11][CH2:12][CH2:13][OH:14]>C(O)CCC>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:11][CH2:12][CH2:13][OH:14])([O-:10])=[O:9]

参加物

4

反応物 2

HCID 700EthanolamineHCID 69451-Chloro-2-nitrobenzene

生成物 1

HCID 78637HC Yellow No. 2収率 75%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

According to the procedure of B. Agai, et al., Tetrahedron, 32, 839, (1976), a solution of 1-chloro-2-nitrobenzene (50.0 g, 0.317 mol) and 2-aminoethanol (116.3 g, 1.904 mol) in nBuOH (400 mL) was heated under reflux for 6 hours. The mixture was concentrated, taken up in H2O, and extracted with ether. The organic phase was washed with brine, dried, and concentrated to give 43.1 g (75%) of an orange solid m.p. 78° C.

後処理

  1. temperatureunder reflux for 6 hours
  2. concentrationThe mixture was concentrated
  3. extractionextracted with ether
  4. washThe organic phase was washed with brine
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-1f4484d822da47bfbade65dabe13df54
出典データセット
uspto-grants-1992_09
特許番号
US05149700

関連ノート

読み込み中…