Phenol → HCID 14789659、化合物

HRID 1886097ノート

反応式

HRID 1886097 の反応式
CN(C[C@@H:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C@H:6]1[OH:14])C.[C:15]1(O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[N:22]([C:29](OCC)=O)=NC(OCC)=O.O1CCC[CH2:35]1>>[O:14]([C@@H:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:13][C@H:5]1[N:22]([CH3:29])[CH3:35])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 4

HCID 996PhenolHCID 8028Tetrahydrofuran2 回HCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 22845150HCID 22845150、化合物

生成物 1

HCID 14789659HCID 14789659、化合物

実験手順

Stir a solution of TRANS-2,3-dihydro-2-dimethylamino methyl-inden-1-ol (7.65 g, 0.04 M) triphenylphosphine (11.54 g, 0.044 M), and phenol (4.14 g, 0.044 M) in 100 ml of tetrahydrofuran. Slowly add a solution of diethyl azodicarboxylate in 50 ml of tetrahydrofuran dropwise. Stir the mixture overnight and evaporate the solvent. Take up the residue in ether, filter insoluble material and reconcentrate. Chromatograph the residue on silica gel eluting with ether to yield two isomers, CIS and TRANS, with the CIS isomer eluting first.

後処理

  1. customevaporate the solvent
  2. filtrationfilter insoluble material and reconcentrate
  3. customChromatograph the residue on silica gel eluting with ether to yield two isomers, CIS
  4. washeluting first

出典と根拠

ORDレコード
ord-e54fde7e00b444fabcba31c2e01a8436
出典データセット
uspto-grants-1992_09
特許番号
US05149714

反応ノート

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