5-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one → 6-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one

HRID 1886150ノート

反応式

HRID 1886150 の反応式
[F:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1>O1CCCC1.[C].[Pd]>[NH2:12][C:3]1[C:2]([F:1])=[CH:11][C:6]2[NH:7][C:8](=[O:10])[O:9][C:5]=2[CH:4]=1

参加物

4

反応物 1

HCID 112178355-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one

生成物 1

HCID 156759596-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one収率 107.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 5-fluoro-6-nitro-2(3H)-benzoxazolone (20 g, 0.1 mole) in 300 ml tetrahydrofuran was added 2 g palladium carbon (5%) under nitrogen atmosphere. The mixture was hydrogenated with a Parr shaker for 10 hours at 45 psi. The precipitate which resulted from hydrogenation was redissolved by adding tetrahydrofuran. The catalyst was removed by filtration and the filtrate was concentrated to give 18.1 g of the title compound as a brown solid: m.p. 180°-182° C. (dec.).

後処理

  1. customThe precipitate which resulted from hydrogenation
  2. dissolutionwas redissolved
  3. customThe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-8c23a550a38c457c85ee5b7ec5c093fb
出典データセット
uspto-grants-1992_09
特許番号
US05149821

反応ノート

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