1-Hexanol → (R)-(+)-2,3-EPOXYPROPYL HEXYL ETHER
反応式
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH-].[Na+].[CH2:10]([C@@H:12]1[O:14][CH2:13]1)Cl>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH2:1]([O:7][CH2:10][C@@H:12]1[O:14][CH2:13]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]参加物
6
実験手順
6 ml of n-hexanol was added dropwise to a mixture of 40 g of 50% sodium hydroxide solution, 24 g of (R)-epichlorohydrine as used in the Synthetic Example 1 and 400 mg of tetrabutylammoniumhydrogen sulfate, under cooling at 20° to 25° C. The reaction solution was stirred at the same temperature for 3 hours and added with water, and then the product was extracted into ether. The extracted product was distilled under reduced pressure to obtain 3.35 g of (R)-n-hexylglycidylether.
後処理
- temperatureunder cooling at 20° to 25° C
- extractionthe product was extracted into ether
- distillationThe extracted product was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-b780f9ff94fe42f39fca6cc855ac2e19
- 出典データセット
- uspto-grants-1992_09
- 特許番号
- US05151214
反応ノート
読み込み中…