Acetic Acid → 6-(4-Hydroxyphenyl)-2-naphthalenecarboxylic acid

HRID 1886552ノート

反応式

HRID 1886552 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)=[CH:5][CH:4]=1.C(O)(=O)C.C(OC(=O)C)(=O)C.Br>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 7918Acetic AnhydrideHCID 150998986-(4-Methoxyphenyl)naphthalene-2-carboxylic acid

生成物 1

HCID 150998996-(4-Hydroxyphenyl)-2-naphthalenecarboxylic acid収率 82.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a four-necked flask equipped with a stirring rod, dropping funnel, reflux condenser and thermometer was charged 0.63 g (0.0023 mol) of 2-(4'-methoxyphenyl)naphthalene-6-carboxylic acid of Example 9. To the compound were added 50 ml of acetic acid, 30 ml of acetic anhydride and 15 ml of 48% hydrobromic acid. The reaction was continued for 10 hours while the mixture was being heated with stirring, thereby obtaining clear solution. When 50 ml of water was added to the reaction solution, white precipitate was obtained. The precipitate was separated from the mixture by filtration, and then dried to obtain 0.5 g of 2-(4'-hydroxyphenyl)naphthalene-6-carboxylic acid. The yield of the product was 82 mol % on the basis of 2-(4'-methoxyphenyl)naphthalene-6-carboxylic acid used. The purity of the produce was 98%.

後処理

  1. customInto a four-necked flask equipped with a stirring rod
  2. temperaturereflux condenser
  3. temperaturewas being heated
  4. customobtaining clear solution
  5. customwhite precipitate was obtained
  6. customThe precipitate was separated from the mixture by filtration
  7. customdried

出典と根拠

ORDレコード
ord-369699fa892e4009a68ba0d2e2780ee1
出典データセット
uspto-grants-1992_09
特許番号
US05151549

反応ノート

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