Benzene → HCID 15053443、化合物

HRID 1886646ノート

反応式

HRID 1886646 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:22]([NH2:25])[C:23]#[CH:24].C1C=CC=CC=1>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH:25][CH2:22][C:23]#[CH:24])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 241BenzeneHCID 11430Potassium CarbonateHCID 239041PropargylamineHCID 15042229HCID 15042229、化合物

生成物 1

HCID 15053443HCID 15053443、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A stirred mixture of 7.4 g (0.03 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride and 4.5 g (0.03 mole) of potassium carbonate in 20 ml of tetrahydrofuran was treated with 1.7 g (0.03 mole) of 2-propynylamine added dropwise from a needle and syringe. After stirring for 16 hr, the reaction mixture was diluted with 400 ml of water and the resulting tan solid was collected by filtration, yielding 7.7 g of crude product. Repeated triturations of the crude product with hot benzene gave upon combining and cooling 1.2 g (15.2%) of tan powder, m.p. 120°-122° C.

後処理

  1. additionadded dropwise from a needle and syringe
  2. filtrationthe resulting tan solid was collected by filtration
  3. customyielding 7.7 g of crude product

出典と根拠

ORDレコード
ord-5f018280b9244d4b8870360e9d89447d
出典データセット
uspto-grants-1992_09
特許番号
US05151418

反応ノート

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