Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 1886742ノート

反応式

HRID 1886742 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

生成物 1

HCID 2474Bupivacaine (USAN:INN:BAN)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

後処理

  1. customto precipitate the Bupivacaine base
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

出典と根拠

ORDレコード
ord-810d63d043b34203ab16d47ebf78540b
出典データセット
uspto-grants-2013_08
特許番号
US08501215B2

反応ノート

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