Triethylamine → HCID 58341775、化合物

HRID 1886764ノート

反応式

HRID 1886764 の反応式
C(N(CC)CC)C.[C:8](Cl)(=[O:12])[C:9]([CH3:11])=[CH2:10].[CH:14]1[C:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH:24]([OH:25])[C:18]=2[CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[C:8]([O:25][CH:24]1[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:19]=2[CH2:20][CH2:21][CH2:22][CH2:23]1)(=[O:12])[C:9]([CH3:11])=[CH2:10]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 371715H-Benzocyclohepten-5-ol, 6,7,8,9-tetrahydro-

生成物 1

HCID 58341775HCID 58341775、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

With stirring and ice cooling, 111 g of triethylamine was added to a mixture of 120 g of methacrylic acid chloride, 240 g of 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol, and 1500 g of toluene. The mixture was stirred at room temperature for 16 hours. By standard aqueous work-up and solvent distillation, a crude product was obtained. It was purified by column chromatography, yielding the target compound, 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl methacrylate.

後処理

  1. stirringThe mixture was stirred at room temperature for 16 hours
  2. distillationBy standard aqueous work-up and solvent distillation
  3. customa crude product was obtained
  4. customIt was purified by column chromatography

出典と根拠

ORDレコード
ord-d5e9550cd5d44f6fab851a603c5d5035
出典データセット
uspto-grants-2013_08
特許番号
US08501384B2

反応ノート

読み込み中…