Phenyl isocyanate → 1-Phenyl-3-(2-phenylbenzo[d]oxazol-5-yl)urea

HRID 1886919

反応式

HRID 1886919 の反応式
[C:1]1([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClCCl>[C:17]1([NH:23][C:24]([NH:16][C:13]2[CH:14]=[CH:15][C:9]3[O:8][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[N:11][C:10]=3[CH:12]=2)=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 7210592-Phenyl-1,3-benzoxazol-5-amine

生成物 1

HCID 673325081-Phenyl-3-(2-phenylbenzo[d]oxazol-5-yl)urea収率 85%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2-phenylbenzo[d]oxazol-5-amine (75 mg, 0.36 mmol) in dichloromethane (2 mL) at room temperature was added phenyl isocyanate (43 μL, 0.39 mmol). The solution was stirred at room temperature for 16 h. The resulting precipitate was filtered off and washed with dichloromethane to afford 99.9 mg (85%) of the title compound (LCMS RT=6.45 min, MH+ 330.1)

後処理

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with dichloromethane

出典と根拠

ORDレコード
ord-c3b535fff2704f91b0ee1b438bd2f08f
出典データセット
uspto-grants-2013_08
特許番号
US08501713B2

関連ノート

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