Ethanol → Ethyl (2-aminoethyl)(methyl)phosphinate

HRID 1886999ノート

反応式

HRID 1886999 の反応式
[CH2:1]([O:3][P:4]([CH2:7][CH2:8][NH:9]C(OCC1C=CC=CC=1)=O)([CH3:6])=[O:5])[CH3:2].CCO>[Pd].CCOC(C)=O>[CH2:1]([O:3][P:4]([CH2:7][CH2:8][NH2:9])([CH3:6])=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 702EthanolHCID 67033999(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester

生成物 1

HCID 85676205Ethyl (2-aminoethyl)(methyl)phosphinate収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester (1.3 g, 4.56 mmol) and 10% Pd/C (485 mg) were combined in a flask and EtOH (46 mL) was added. The reaction flask atmosphere was exchanged for H2 and the reaction was run at room temperature until complete, as determined by TLC (eluent: 100% EtOAc). The reaction was then filtered through Supercell NF and the filtrate was concentrated to yield (2-amino-ethyl)-methyl-phosphinic acid ethyl ester (615 mg, 90%) as a yellow oil in which white crystals began to form under high vacuum.

後処理

  1. customwas run at room temperature
  2. filtrationThe reaction was then filtered through Supercell NF
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c96f73aeb964487aa33ffdb38e1e0127
出典データセット
uspto-grants-2013_08
特許番号
US08501714B2

反応ノート

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