4,5-difluoro-N-methyl-2-nitrobenzamide → HCID 57974170、化合物

HRID 1887699ノート

反応式

HRID 1887699 の反応式
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([N+:13]([O-])=O)[CH:3]=1.[H][H]>CO.[Pd]>[NH2:13][C:4]1[CH:3]=[C:2]([F:1])[C:11]([F:12])=[CH:10][C:5]=1[C:6]([NH:8][CH3:9])=[O:7]

参加物

5

反応物 2

HCID 619939344,5-difluoro-N-methyl-2-nitrobenzamideHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 57974170HCID 57974170、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To 4,5-difluoro-N-methyl-2-nitrobenzamide (1.33 g, 6.15 mmol) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 200 mg, 15 wt %) under argon. A hydrogen balloon was used as hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed the crude was purified by silica gel chromatography to obtain the desired product (quantitative yield).

後処理

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed the crude
  4. customwas purified by silica gel chromatography

出典と根拠

ORDレコード
ord-c3b9679742b84d70a16bb2de293a8d62
出典データセット
uspto-grants-2013_08
特許番号
US08501763B2

反応ノート

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