Isopropylamine → N-isopropyl-2-nitrobenzenesulfonamide

HRID 1887709ノート

反応式

HRID 1887709 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([O-:3])=[O:2].[CH:14]([NH2:17])([CH3:16])[CH3:15].CCN(CC)CC>CO>[CH:14]([NH:17][S:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])(=[O:12])=[O:11])([CH3:16])[CH3:15]

参加物

5

反応物 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 155402-Nitrobenzenesulfonyl chloride

生成物 1

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamide収率 63%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To the solution of 2-nitrobenzene-1-sulfonyl chloride (1.11 g, 5.0 mmol) in MeOH (30 mL) was added isopropylamine (0.85 mL, 2.0 eq) and Et3N (1.4 mL, 2.0 eq). The mixture was stirred overnight at room temperature. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product N-isopropyl-2-nitrobenzenesulfonamide (0.774 g, isolated yield 63%).

後処理

  1. customThe solvent was removed
  2. customthe crude was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-29352af446574d9ab7712363069a2ad9
出典データセット
uspto-grants-2013_08
特許番号
US08501763B2

反応ノート

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